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Various factors, including hypoxia, oxidative stress, protein mutations, nutrient deficiency, or viral infections, can lead to an impairment of ER functionality reducing its capacity for protein folding, which causes accumulation of misfolded proteins [[445], [446], [447]]

Summary Lutein and zeaxanthin are overall safe to supplement at the recommended doses, but more research is required to assess the potential health effects

10.1016/j.febslet.2009.03.038 101 OkamotoH.IshikawaA.YoshitakeY.KodamaN.NishimutaM.FukuwatariT.et al (2003)

[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Awad M., Aldosari S., Abid M.R

Author: Eileen Shepherd is clinical editor at Nursing Times

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