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Meanwhile, this finding revealed it could suppress ferroptosis by activating the SIRT3 pathway to reduce myocardial damage, which provided a new perspective for the study of Entresto in DKD[176]

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However, this large number warrants important context: 35 of the 36 studies included in the systematic review were preclinical (conducted in laboratory or animal models), and only one clinical study met the review's inclusion criteria

TSA also inhibited VDAC1-mediated mPTP opening and apoptosis (96)

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