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NF-B activation can induce the expression of pro-inflammatory cytokines, chemokines, adhesion molecules, and matrix metalloproteinases, which contribute to the recruitment of inflammatory cells, tissue damage, and remodeling in PF 18

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These observations are consistent with those of several studies on resveratrol supplementation (22)

Brazilin, a main active ingredient of Sappan wood, has been proved has antitumor effects by actuating ferroptosis

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Previous studies indicate that vitamin C reduces the synthesis and release of proinflammatory factors, such as IL-1 and TNF-, by reducing the transcription of their genes (44,45)