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[1] Toxicity is extremely rare, though adverse reactions including hypersensitivity can occur, particularly with injectable forms

FDA approval is the most significant regulatory difference

In a PD model, the modeled rats were observed with compromised BBB and markedly elevated IL-17A levels in the SN (Li et al., 2019)

Sensory nerve fibers and autonomic nerve fibers are involved in bone tissue control (278), but skeletal nerves have the potential to affect intestinal activity indirectly through the ANS and ENS (279, 280)

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Therefore, we recommend that companies start working on these no later than the beginning of 2026