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Increased Basal Metabolic Rate (BMR) By inhibiting NNMT, 5-Amino-1MQ preserves NAD, which supports mitochondrial efficiency and thermogenesis increasing resting calorie burn even during caloric restriction

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13 These and other studies have established CD38-directed monoclonal antibodies in combination regimens as a standard of care across multiple lines of therapy for relapsed/refractory multiple myeloma

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Absorption is rapid regardless of route (peak plasma levels within 3090 minutes), and theres no evidence that route of administration affects NNMT inhibition efficacy

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