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Recombinant human IGF-1, given over 6 months at a dose FDA-approved for long-term treatment of growth failure in children with severe primary IGF-1 deficiency, reduced coronary artery atherosclerosis and promoted a stable plaque phenotype in a pig model of familial hypercholesterolemia (FH) (148)

Simultaneous activation of Erk1/2 and Akt signaling is critical for formononetin-induced promotion of endothelial function
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