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Cancer Cell 19 , 416428 (2011)

Dosing Considerations for Combined Therapy Establishing appropriate dosing for combined BPC-157 and cryotherapy protocols requires understanding both the peptide pharmacology and the physiological responses to cold exposure

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doi: 10.1186/s12966-017-0627-3 184

J., Sakamoto, N

However, their therapeutic potential could be limited as a protracted use will lead to tolerance to analgesic effects requiring escalating doses that is associated with side effects such as respiratory depression