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While pyridoxine (vitamin B6) is typically considered helpful in reducing vomiting and nausea, the American Academy of Family Physicians (AAFP) mentions that cyanocobalamin (vitamin B12) also significantly reduced vomiting episodes in pregnant women compared with placebo, indicating its role in nausea and vomiting management

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Although clinical trials specifically for MASH have not yet been conducted, preclinical studies confirm significant regulatory effects on hepatic metabolism, providing a novel strategy for targeted MASH therapy and supporting future translational research