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The causes can be complex and often involve multiple factors working together

Circulation 127 , 11161127 (2013)

The extent of protein binding of bioactive molecules might impact pharmacokinetic and pharmacodynamic features (58)

The results showed that Tanzeum bound with slightly faster association and dissociation rates than GLP-1 WT, resulting in a 1.5-fold difference in binding affinity to the receptor (Tanzeum: 76.1 nM

Reversible and irreversible thiol oxidation processes Cells spend considerable energetic efforts to prevent non-specific thiol oxidation reactions while allowing the controlled formation of protein disulfide bonds or other oxidative thiol modifications that play physiologically relevant roles

J., & Ki, S