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Research published in eBioMedicine demonstrates that cagrilintide exerts its weight-lowering effects specifically through AMY1R and AMY3R receptors, with the brain serving as the primary site of action

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doi: 10.1038/s41575-018-0061-2 203 ZollnerA.KochR.JukicA.PfisterA.MeyerM.RsslerA.et al

As the main source of circulating lipids, the increased secretion of FFAs from adipose tissue is strongly associated with enhanced lipolysis, in particular increased triglyceride (TG) hydrolysis

We next investigated whether innate fear could reverse the SNI-induced hyperexcitability of MD neurons

Together, these results show that ER homeostasis is sensitive to modulation of the GSSG/GSH ratio
