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This includes confirmed low serum vitamin B12 levels, pernicious anaemia, malabsorption states such as coeliac disease, inflammatory bowel disease, or post-gastric or bariatric surgery, unexplained anaemia, neuropathy or neurological symptoms consistent with vitamin B12 deficiency, a long-term vegan diet with symptoms or low levels, or failure of oral vitamin B12 supplementation

[DOI] [PubMed] [Google Scholar] 60.Deboer MD, Marks DL

Vitamin B6: Necessary for proper vitamin B12 absorption

Along with its role in metabolism and the production of red blood cells, vitamin B6 can [3]: Help support normal immune system function Encourage cognitive development during pregnancy and the first few months of life Promote production of lymphocytes (white blood cells) Help with the production of neurotransmitters like dopamine and serotonin In other words, vitamin B6 is essential to health and well-being

It could help with weight loss by helping one consume a lower number of calories, by making one feel more full, and by making one less hungry

Since B12 cannot be made by the body, it has to be procured from food or supplements