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Compared with normal animals, Nrf2-deficient mice have more pronounced effects on lipopolysaccharide (LPS)-induced microglial activation and inflammatory response, with lower levels of IL-1, IL-6, IL-12, and TNF- in the brain ( Moreover, increasing evidence indicated that Nrf2 may regulate mitochondrial function and metabolism

Secukinumab in moderate-to-severe hidradenitis suppurativa (SUNSHINE and SUNRISE): week 16 and week 52 results of two identical, multicentre, randomised, placebo-controlled, double-blind Phase 3 trials

doi: 10.1016/S0166-2236(02)02215-4 15 WangHHeYSunZRenSLiuMWangGet al

Another issue waiting for more studies was the influence between IF and nervous system on obese subjects

Methods A PRISMA-guided systematic review (Figure 1) was performed using PubMed and MEDLINE databases, employing search terms glutathione AND topical AND skin OR dermatology, yielding 446 articles with no time restriction

hence, its treatment involves a combination of surgery, radiation therapy, and chemotherapy