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The cells simply cannot generate the energy required to meet the demands of daily life, leaving patients profoundly fatigued and functionally impaired

J Orthomolec Psych 1983

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This study defined glutathione as a first line of defense against oxidative stress

At the metabolic level, increased matrix stiffness impairs the synthesis of anti-fibrotic lipid mediator PGE2 and reduces expression of rate-limiting prostaglandin biosynthetic enzyme cyclooxygenase 2 (COX-2) and prostaglandin E synthesis (PTGES) through p38/MAPK signaling pathway (Berhan et al., 2020)

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