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Test models have suggested relatively rapid turnover

Upon its accumulation and phosphorylation, HIF-1 dimerizes with HIF- (constitutively expressed nuclear proteins), enters the nucleus, and promotes the transcription of hypoxia response elements (HRE)-containing target genes involved in energy metabolism, erythropoiesis, vascular remodelling, and other processes (Fig

Therapeutic potential of SIRT1 activators in MASLD Previous studies have shown that SIRT1 plays a central regulatory role in multiple pathological processes of MASLD, including lipid metabolism disorders, insulin resistance, immune activation, oxidative stress, and gutliver barrier dysfunction