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RhoA/ROCK is not merely an independent pathway but a mediator of endothelial dysfunction, smooth muscle contraction, and fibrotic remodeling ( Figure 4 ) (161)

MECP2 structure and function might be modulated through post-translational modifications, such as phosphorylation, acetylation, methylation, and ubiquitination

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Notably, weight loss appeared to be exposure-dependent, with the cohort receiving the maximum dose of 2 mg/day for the entire study exhibiting the greatest weight loss ( Table 2 )

All authors have reviewed and agreed to the publication of the manuscript

An evaluation of the impact of Adriamycin on metabolic pathways was performed based on a tool for metabolomic data analysis available online