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However, polar aprotic solvents like acetone are good for dissolving it ( 2.1 Bioactive compounds of milk thistle The primary bioactive constituents of Silybum marianum (milk thistle, MT) (Figure 1c), collectively referred to as silymarin, are predominantly flavonolignans namely silybin A (PubChem CID: 31553), silybin B (PubChem CID: 1548994), isosilybin A (PubChem CID: 11059920), isosilybin B (PubChem CID: 10885340), silydianin (PubChem CID: 11982272), and silychristin (PubChem CID: 441764) alongside flavonoids such as taxifolin (PubChem CID: 439533) and quercetin (PubChem CID: 5280343), as well as other polyphenolic compounds

While this combination theoretically may improve sperm quality through multiple pathways, clinical studies are still needed to verify its specific effects on fertility parameters (210)