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In this narrative review, we discuss the known therapeutic effects of heat and cold modalities, and explore their individual and combined physiological mechanisms

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63 Moreover, mucosal inflammation in claudin-7 KO mice appears to be a product of epithelial cell instability and not necessarily the result of barrier deregulation, given that no apparent gut leakiness was documented at early time points in these mice

All authors contributed, revised, and approved the final version of the manuscript