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The level of 3-bromotyrosine, a unique product of EPO and eosinophils, was found to be 3 times higher in the bronchoalveolar lavage (BAL) fluid of individuals with asthma compared with that in the control subjects [31]

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In parallel, it inhibits activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) pathway and suppresses NLRP3 inflammasome activation, resulting in decreased production of inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF)

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