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A questo proposito alcune ricerche suggeriscono che i batteri intestinali potrebbero metabolizzare la carnitina non assorbita per formare TMAO e gamma-butirrobetaina, sostanze associate a un possibile aumento del rischio di malattie cardiovascolari

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Nutrients 16(15)

Some research suggests that chronic high-dose L-carnitine supplementation may increase TMAO levels via gut bacteria metabolism, and elevated TMAO has been associated with increased cardiovascular risk in observational studies

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Previous studies have shown that thapsigargin-induced ER stress increases SREBP2 levels in Huh-7 hepatocytes (14)