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External resources for tirzepatide and B12 research Clinical trial data for tirzepatide weight loss efficacy comes primarily from the SURMOUNT trial series published in The New England Journal of Medicine

While all B vitamins play roles in energy metabolism and cell health, B12 is especially crucial for brain, nerve, and blood function

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For most people, B12 can be taken at any time of day without affecting sleep, though morning dosing is often recommended for consistency and to address any individual sensitivity