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It has also been demonstrated that inhibitory GABAergic CNS GIPR + neurons are necessary for the food intake reducing effects of GIPR agonists and dual incretin co-agonists (54, 55), while excitatory glutamatergic CNS GLP-1R + neurons are necessary for the food intake reducing effects of GLP-1R agonists (71)

In the STEP 4 and SURMOUNT-4 trials funded by Novo Nordisk and Eli Lilly where patients abruptly discontinued medication, many of them were not at a normal BMI at withdrawal and regained most of the weight they lost

In separate studies, oral Wegovy led to roughly 14% body weight reduction over 64 weeks, while Foundayo achieved about an 11% reduction over 72 weeks

Washington, Towson, and throughout the greater Baltimore area who are navigating eating disorders, disordered eating, and the complex questions that arise when mental health and medical treatment intersect

The table below summarizes each schedule

Dont extend past the BUD even if theres medication left
