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It has also been demonstrated that inhibitory GABAergic CNS GIPR + neurons are necessary for the food intake reducing effects of GIPR agonists and dual incretin co-agonists (54, 55), while excitatory glutamatergic CNS GLP-1R + neurons are necessary for the food intake reducing effects of GLP-1R agonists (71)

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In the STEP 4 and SURMOUNT-4 trials funded by Novo Nordisk and Eli Lilly where patients abruptly discontinued medication, many of them were not at a normal BMI at withdrawal and regained most of the weight they lost

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In separate studies, oral Wegovy led to roughly 14% body weight reduction over 64 weeks, while Foundayo achieved about an 11% reduction over 72 weeks

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