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Benralizumab, an anti-interleukin-5 receptor a monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial

These LL-37/DNA complexes are potent activators of plasmacytoid dendritic cells, triggering massive production of type I interferons, the same cytokines that drive the "interferon signature" characteristic of active lupus

The studied escalation started at 2mg weekly and increased by 2mg every 4 weeks to a 12mg maintenance dose

H1299 cells were cultured in DMEM Hi-glucose medium, with 10% FBS and 0.5 U/ml P/S only

Springer Netherlands, Dordrecht, pp 259280 Bloch K (1949) The synthesis of glutathione in isolated liver