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De novo PC synthesis begins with the phosphorylation of choline by the enzyme choline kinase (ChoK) into phosphocholine (27) ( Figure 2 )

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Similarly, a decreased glycolytic reserve has been found in NK cells from ME/CFS patients (389) and metabolomic analyses have revealed compromised ATP production via the tricarboxylic acid (TCA) cycle (389)

however, whether this is causative, or merely a marker of poor health, remains unclear (Tang et al., 2013

We observed decreased levels of 3,4-hydroxyphenyl lactate in RTT