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This investigation's small sample size of 80 individuals and focus on safety rather than efficacy make a Phase 3 trial unlikely

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The mitochondrial DOX-Fe 2+ complex induces triggers lipid peroxidation, resulting in mitochondria-dependent ferroptosis and decreased cardiac function in mice, which is reflected in significantly reduced left ventricular ejection fraction and myocardial fibrosis

Cardiol Rev 33(4):359 Murphy CJ, Oudit GY (2010) Iron-overload cardiomyopathy: pathophysiology, diagnosis, and treatment

A.SarkakiA.GoudarziG.KhorsandiL

FeSOD-A gene amplification increases the FeSOD protein expression and enzyme activity in a induced resistance to benznidazole and gentian violet treatments [73]