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When there is low vitamin B12 in the body, there is less production of these neurotransmitters, which causes mood disorders or depression

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Vitamin C in Health and Disease

Leveraging the cartilage matrix as a drug reservoir while minimizing potential systemic toxicity holds particular significance in addressing the chronic nature of OA and its high prevalence of comorbidities

Coarse control mechanisms including mitochondrial fission and fusion, changes in cristae structure, respirasome assembly, protein complex assembly, protein degradation and expression of nuclear and mitochondrial genes play intricate roles in modulating ATP output by mitochondria

In summary, the HPA axis is a key component of the MGBA, and a possible mechanism is that VNS modulates PD-related neuropsychiatric symptoms by regulating HPA axis function via the vagus nerve