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318,319,320 Furthermore, stability can be improved without compromising drug activity by optimizing the number and modification positions of 2-F and 2-OME groups on both strands of double-stranded siRNA, leading to substantial efficacy improvements

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This helps to avoid potential adverse reactions

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Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control

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