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At first, cystathionine -synthase and cystathionine -lyase were believed to be the key enzymes responsible for supersulfide production via the transsulfuration pathway (21)

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Researchers must also generate non-clinical evidence demonstrating that the compound interacts with the intended target and produces the expected pharmacological effects without showing major safety concerns

Also, in the liver, similar to ADx + CORT, only Bmal1 increased, but Per2 and Rev-erb remained unchanged (Supplementary Fig
