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In the case of lung adenocarcinomas, LKB1 loss of function has been identified associated with alterations in oncogenic pathways and mitochondrial metabolism [172]

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doi: 95

doi: 10.1021/acs.jafc.8b00917

Biochem Biophys Res Commun 205(2):10641071 Cederbaum AI et al (2012) CYP2E1 sensitizes the liver to LPS- and TNF -induced toxicity via elevated oxidative and nitrosative stress and activation of ASK-1 and JNK mitogen-activated kinases

Wherever possible, calibrate with defined oxidant fluxes (enzymatic generators), internal standards, or ratiometric reporters and fully report matrix and environmental conditions (buffer composition, protein content, temperature, pH, oxygen tension, light exposure) plus acquisition timing/kinetics to separate bursts from steady states (Kalyanaraman et al