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Encouraged by the superior therapeutic effect of the combination therapy in the Panc-1/PSC subcutaneous model, we further evaluated this combinatorial strategy in an orthotopic pancreatic tumour mouse model, which was established by co-inoculation of mice with luciferase-expressing Panc-1 cells (Panc-1-luci) and PSCs

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Conversely, M-siTGF-1 treatment ameliorated lung histopathological damage and maintained normal lung morphology and hindered the accumulation of collagen caused by exposure to BLM (Fig

Nat Rev Mol Cell Biol 15(2):8194 May MJ, Madge LA (2007) Caspase inhibition sensitizes inhibitor of NF-kappaB kinase beta-deficient fibroblasts to caspase-independent cell death via the generation of reactive oxygen species