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Generally, the major pathological changes of PAH are vasoconstriction and vascular remodelling of the small pulmonary arteries (Tuder et al., 2009) involving the thickening of the intima-media, smooth muscle cell proliferation, endothelial cell proliferative lesions formation, vascular inflammation and immune dysregulation (Tuder et al., 2007

A clear association between alcohol abuse and the development of ARDS was not clearly observed, however, the incidence of ARDS was about 70% in patients with a prior history of alcohol-related illness compared to 39% in those with no history of alcohol-related illness

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Additionally, in another clinical study targeting SLE, a bispecific approach simultaneously targeting BCMA and CD19 was employed

SIH displayed lower toxicity after 24 h of incubation

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