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Notably, ergothioneine emerged as the plasma metabolite most strongly linked to a decreased risk of coronary disease (p=0.01), cardiovascular mortality (p=0.002), and overall mortality (p=0.0004)

In humans, night workers have been observed to exhibit elevated systemic markers of oxidative stress (e.g., plasma protein oxidation) and reduced antioxidant defenses (e.g., CAT, SOD, and GPx) when compared to their day worker counterparts (Teixeira et al

PullieroAGodschalkRAndreassiMGCurfsDVan SchootenFJIzzottiA

10.1016/j.archger.2006.02.003

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Massive apoptosis of colonocytes induced by butyrate deprivation overloads resident macrophages and promotes the recruitment of circulating monocytes