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The Case We saw quite an interesting toxicology case in the emergency department the other day, which highlights some of the major issues in an increasingly common toxic presentation to departments: valproic acid toxicity

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10.1042/0264-6021:3430281 Biochem

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Important safety warning seek urgent medical attention if you experience any of the following: Severe or persistent abdominal pain (which may indicate acute pancreatitis) Right upper quadrant pain, fever, or jaundice (which may indicate gallbladder disease) Reduced urine output, dizziness, or signs of dehydration (which may indicate acute kidney injury) Severe nausea or vomiting preventing adequate fluid intake Signs of a serious allergic reaction (swelling, difficulty breathing, rash) Symptoms of hypoglycaemia such as dizziness, sweating, or confusion These may represent serious adverse effects requiring prompt clinical assessment

Utility of plasma concentration of trimethylamine n-oxide in predicting cardiovascular and renal complications in individuals with type 1 diabetes