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By operating with GSH as its reducing substrate, GPX4 exhibits remarkable efficacy against diverse lipid peroxidation products, thereby blocking cell death induced by cytoplasmic or mitochondrial ROS and lipid peroxidation [48]

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Since the synthesis of one HER molecule requires one His molecule and three Met molecules, it is very likely that the biosynthetic steps of Met and SAM are rate-limiting in ERG production

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Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen