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GSTM1 contributes to detoxifying many pollutants and smoke-derived toxins, so the null genotype can increase sensitivity to air pollution, tobacco smoke, and some chemicals

The cellular mevalonate pathway produces isopentyl pyrophosphate (IPP) which that facilitate GPX4 protein synthesis

Mhaimeed O, Burney ZA, Schott SL et al (2024) The importance of LDL-C lowering in atherosclerotic cardiovascular disease prevention: lower for longer is better

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However, these protons are tightly bound to the hydroxyl group once dopamine is inside monoaminergic synaptic vesicles, which have a relatively low pH