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It has been suggested that a combination of genetic factors [e.g., variation at human leukocyte antigen (HLA) loci], environmental exposures (e.g., smoking), and the microbiota contribute to the development of RA (Smolen et al., 2018)

Interleukin-13 receptor subunit alpha 2 induces chemokine expression and macrophage polarization to promote inflammation and fibrosis

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Importantly, treatment of DIO mice with our NNMT inhibitors did not impact food intake, but produced marked reductions in body weight, WAT mass, adipocyte size, and cholesterol levels with negligible toxicity or observable adverse effects

The cell medium was aspirated and the cells on the coverslips were washed with PBS

The next day, the precipitate was collected by centrifugation and dried under low heat