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Low oral bioavailability of macromolecular drugs stems mainly from pre-systemic enzymatic degradation and poor penetration across the intestinal membrane (Hamman et al., 2005)
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The mucus-degrading species Akkermansia , known to contribute to reduced intestinal barrier function, was detected in the caecum and colon of H
Gamma-aminobutyric acid (GABA) is a well-known neurotransmitter that inhibits neurotransmission in insects by binding to specific receptors
[DOI] [PMC free article] [PubMed] [Google Scholar] McGuinness M, Mazurkiewicz V, Brennan E, Dowling D
