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2.4 Multiple sclerosis (MS) Gut dysbiosis is seen in MS patients as marked by decreased microbial diversity and shifts among specific taxa, like increased Akkermansia and reduced SCFA-producers (Jangi et al., 2016)

doi: 10.1093/jn/131.10.2991 61 TurnerFSmithGSachseCLightfootTGarnerRCWolfCRet al

Cells corresponding to at least 3,000-fold library representation were sorted per each sample replicate

Additionally, zebrafish embryos demonstrated no morphological abnormalities, toxicity, or changes in hatching, survival, or heart rates following exposure to puerarin-loaded PLGA nanopartilces 134

78420) and 0.5 M EDTA solution (Thermo Scientific

The peptide does not bind to a single identified receptor but instead modulates several biological systems simultaneously