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Studies have shown that folate deficiency, such as exposure to the dihydrofolate reductase inhibitor methotrexate, reduces hippocampal neural stem cell proliferation and is accompanied by an increased rate of apoptosis in neonatal neurons, leading to hippocampal volume atrophy and affecting memory and cognitive function [91]

Complement activation, cytotoxicity, and alterations in cell junction proteins (e.g., reduced connexin-43) may also exacerbate tissue injury(Wroska et al., 2024)

Dario Zamboni (University of So Paulo, Ribeiro Preto, Brazil)

Oral delivery of staphylococcal nuclease ameliorates DSS induced ulcerative colitis in mice via degrading intestinal neutrophil extracellular traps

10.1042/bj3170659 Biochem