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OSET Orthopaedic Summit 2017, Las Vegas 12/8/2017 Panelist: Lumbar Spine postsurgical complications in the young and old

These findings warrant further investigation of the adaptations that various tumors may employ to augment limited glutamine levels

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These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time

These findings suggest that oral administration of glutathione may increase the incorporation of protein-bound glutathione into the liver or decrease the pathological excretion of glutathione from the liver