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The dosing regimen of ATZ should be a wide range encompassing environmentally relevant exposure and also achieving toxic threshold, i.e., 0.4 mg/kg, 4 mg/kg, 40 mg/kg, and 400 mg/kg

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While glutathione is generally considered safe when taken in appropriate doses, excessive supplementation can result in side effects like gastrointestinal discomfort, nausea, and allergic reactions

doi: 10.1093/advances/nmy022

Of interest, an enlarged dorsal muscle area was noted in gilthead seabream fed diets supplemented with 2%, 5%, or 8% creatine [42]