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Caffeine, the primary active ingredient, acts through adenosine receptor antagonism and increased calcium release, potentially provoking arrhythmias and myocardial stress

All authors reviewed the manuscript

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[DOI] [Google Scholar] 72.Saletu B., Paulus E., Linzmayer L., Anderer P., Semlitsch H.V., Grnberger J., Wicke L., Neuhold A., Podreka I

CVD is the leading cause of death worldwide, the association with gut microbiota has been reported in recent few years, which is mediated by gut microbiota derived metabolites (Wang et al., 2011