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Since effectiveness of these two drugs in treating COVID-19 is achieved in higher oral doses than usual, various gastrointestinal adverse effects (dysgeusia, dyspepsia, and stomachache) and toxicities (especially cardiac) may appear after oral administration [41, 42]

TMAO also hampers the ability of blood vessels to respond and causes an imbalance of harmful molecules, resulting in damage to the inner lining of blood vessels and atherosclerosis development [118]

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Lactate Promotes Glioma Migration by TGF-2-Dependent Regulation of Matrix Metalloproteinase-2

moreover, it indirectly impacts the brain by impairing the immune system and changing the usual gutbrain link