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doi: 10.3389/fphar.2022.972468

Weeks 1-4: Foundation Phase Don't expect dramatic visible changes in the first month

Preclinical: With increased knowledge of the nose-brain pathway and IN therapeutics, IN-BDNF to mouse models of depression is being explored: in a chronic mild stress (CMS) induced-depression model, mice were given AAV-packaged BDNF fused with cell-penetrating peptides, human immunodeficiency virus-1 transactivator of transcription (TAT), and influenza A hemagglutinin glycoprotein 2 (HA2)

Aggregation: Peptides may aggregate under certain solution conditions, especially at high concentration or upon repeated freezethaw cycles

Example (for a 50mg vial reconstituted in 2 mL of BAC water): Total peptide: 50mg BAC water added: 2 mL Resulting concentration: ~25 mg/mL Recommended practice: Use sterile bacteriostatic water (0.9% benzyl alcohol) for reconstitution

Many of the substances named in the announcement have been explored for their potential roles in areas like tissue repair, immune modulation, metabolic function, and cognitive health