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However, the efficacy of many therapeutic drugs may be compromised by the host BM microenvironment

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New evidence also shows that TDO is overexpressed in uveal melanoma and breast cancer, and correlates with a poor prognosis in breast cancer, which suggests that TDO may be a new target for cancer immunotherapy (Liu et al., 2020)

Duggan et al., enrolled 439 overweight/obese postmenopausal women between the ages of 50 and 75 in a 12-month randomized controlled trial to determine the effects of diet and/or exercise on oxidative stress biomarkers [152]

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