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The [Ca 2+ ] i increases observed in cultured neurons under these conditions may result from a direct excitatory action by binding ionotropic receptors and/or from an indirect effect involving the stimulation of endogenous glutamate synaptic release

The theory of free radicals of oxygen has been known for over 50 years, however, it is only in the last two decades that their role in the development of diseases were discovered and, thus, the beneficial effects of antioxidants have been widely studied (Liu, 2019)

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And like you said, SMART stands for specific, measurable, attainable