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[19] Bertrand included in the concept not only the traditional fats (glycerides), but also the "lipoids", with a complex constitution

Notably, at physiological concentrations, TMAO can enhance the integrity of the bloodbrain barrier through the tight junction regulator annexin A1, limit the reactivity of astrocytes and microglia, and protect the cognitive function of mice from inflammatory challenges

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Likewise, elevated glucose levels should be managed with insulin