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Distribution and tissue retention After absorption, the monoglutamate folates are distributed to tissues and converted to the polyglutamate form by the enzyme folylpolyglutamate synthetase
Changes in expression of regulatory factors after aging may contribute to transcript expression changes that result in pathway dysregulation and consequently some observed detrimental age-related loss of rhythmicity

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Effects of adding L-arginine orally to standard therapy in patients with COVID-19: a randomized, double-blind, placebo-controlled, parallel-group trial