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Skin irritation at the application site is the most reported adverse effect

This means tirzepatide vials tend to be larger (10 to 30 mg vs 5 to 10 mg for semaglutide), and the draw volumes per dose are correspondingly larger

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While not required, a calorie deficit with adequate protein (0.7 to 1.0 grams per pound of goal weight) produces best results

No serious adverse event occurred during the trial and the most frequent treatment-emergent adverse events involved nervous system, QT prolongation, and gastrointestinal disorders

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