glutathione and metalothionein Mechanisms of microbial bioremediation of heavy metals. GSH, Do glutathione and copper interact

GSH undergoes thiol-disulfide exchange in a reaction catalyzed by thiol-transferase as follows: Since this reaction is a reversible reaction, the equilibrium is determined by the redox state of the cell, which depends on the concentrations of GSH and GSSG (proportional to the log of [GSH] 2 /[GSSG]) (Lu, 1999a)

has received grant support from or is a consultant or speaker for Alkermes, AstraZeneca, Auspex, Avanir, Boots, Boehringer Ingelheim, Bristol Myers Squibb, Eli Lilly, Forest, Hoechst Marion Roussel, Intracellular Therapies, Janssen, Karuna, Merck, Neurocrine, NIMH, Novartis, Ortho-McNeil Janssen, Otsuka, Pfizer, Sanofi-Aventis, Shire, SmithKline Beecham, Solvay, Sunovion, Teva, Upjohn, and Wyeth-Ayerst

Chem Res Toxicol 24:30

Common side effects include mild pain, swelling, or redness at the injection site

Thus, purified GST fusion proteins are commonly used to study proteinprotein interactions

Concentrations after 5-6 h fast