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Activating Nrf2 can directly or indirectly transcriptionally upregulate GPX4 expression and cooperatively induce other antioxidant molecules, forming a comprehensive defense network against lipid peroxidation

However it has been reported that the reduction rate of cis,cis,trans-[Pt(NH 3 ) 2 Cl 2 (RCOO)(OH)] monocarboxylato complexes is faster than that of dicarboxylato complexes and this has been attributed to the fact that hydroxido ligands are much better bridging ligands for electron transfer than carboxylate ligands 45

Moreover, more research is needed to show the long-term effects of in ovo supplementation and economic advantages for poultry producers

doi: 10.1177/0379572116652252

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